Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.32 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL898837 | 0.79 | CHRM1 (0.41) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL9002370 | 0.74 | — | — | |
| SCHEMBL9588040 | 0.74 | — | — | |
| SCHEMBL9326012 | 0.72 | — | — | |
| SCHEMBL31171155 | 0.70 | GPR84 (0.41) | GRIK1SLC1A2SLC1A1GRIK2TSHR | |
| SCHEMBL3369505 | 0.68 | CA2 (0.42) | SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL3368465 | 0.67 | GPR84 (0.44) | GRIK1SLC1A2SLC1A1GRIK2 | |
| SCHEMBL6970099 | 0.67 | — | — | |
| SCHEMBL1707213 | 0.65 | CHRM1 (0.39) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL3371201 | 0.65 | GPR84 (0.47) | GRIK1GRIK2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0302296-B1 | PROCESS FOR THE PREPARATION OF A MULTILAYER PROTECTIVE AND/OR DECORATIVE COATING ON A SUBSTRATE SURFACE | BASF Lacke + Farben AG (DE) | 1992-10-21 | — | — | EP | disclosed |
| EP-0377570-A1 | COATING COMPOSITIONS AND PROCESS FOR MANUFACTURING A MULTILAYER PROTECTIVE AND/OR DECORATIVE COAT ON THE SURFACE OF A SUBSTRATE | BASF Lacke + Farben AG (DE) | 1990-07-18 | — | — | EP | disclosed |
| WO-1989001004-A1 | COATING COMPOSITIONS AND PROCESS FOR MANUFACTURING A MULTILAYER PROTECTIVE AND/OR DECORATIVE COAT ON THE SURFACE OF A SUBSTRATE | BASF LACKE + FARBEN AKTIENGESELLSCHAFT (DE) | 1989-02-09 | — | — | WO | disclosed |
| EP-0302296-A1 | Process for the preparation of a multilayer protective and/or decorative coating on a substrate surface | BASF Lacke + Farben AG (DE) | 1989-02-08 | — | — | EP | disclosed |