Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.58 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.57 |
| ▸ | RAB9A | P51151 | 8/20 | 0.57 |
| ▸ | NPC1 | O15118 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719803 | 0.86 | RNF4 (0.57) | LMNASMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL1193236 | 0.86 | PARP10 (0.59) | MEN1KMT2ALMNASMN1; SMN2RAB9A | |
| SCHEMBL11613346 | 0.83 | PARP10 (0.56) | LMNASMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL14037350 | 0.81 | PARP10 (0.52) | LMNAEGFRERBB2ERBB4SMN1; SMN2 | |
| SCHEMBL2170643 | 0.80 | LTA4H (0.76) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9719811 | 0.80 | GPBAR1 (0.62) | MEN1KMT2ASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL22967626 | 0.79 | ALDH1A1 (0.55) | SMN1; SMN2RAB9ANPC1ALDH1A1PARP10 | |
| SCHEMBL23537856 | 0.78 | SMN1; SMN2 (0.58) | LMNASMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL6977226 | 0.78 | ALDH1A1 (0.58) | LMNASMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL22967405 | 0.77 | ALDH1A1 (0.54) | SMN1; SMN2RAB9ANPC1ALDH1A1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157039-A | Lipoxygenase inhibitors | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-10-20 | — | — | US | disclosed |
| US-5109009-A | QUINOLINE AND PYRIDINE COMPOUNDS AND INHIBITION OF 5-LIPOXYGENASES THEREWITH | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-04-28 | — | — | US | disclosed |
| US-4826987-A | Pyridyl and quinoline derivatives | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1989-05-02 | — | — | US | disclosed |