Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RNF4 | P78317 | 1/20 | 0.57 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MITF | O75030 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9719865 | 0.86 | MEN1 (0.62) | PARP10SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL1193236 | 0.83 | PARP10 (0.59) | PARP10SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL9719826 | 0.81 | EGFR (0.59) | SMN1; SMN2NPC1RAB9AHTTGLA | |
| SCHEMBL3224230 | 0.80 | LTA4H (0.76) | RNF4SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL11613346 | 0.80 | PARP10 (0.56) | PARP10SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL18356194 | 0.79 | PARP10 (0.69) | PARP10SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL23537856 | 0.78 | SMN1; SMN2 (0.58) | PARP10SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL14037350 | 0.78 | PARP10 (0.52) | PARP10SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL5485718 | 0.76 | RAB9A (0.74) | PARP10SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL23747359 | 0.76 | CNR1 (0.61) | SMN1; SMN2NPC1RAB9AHTTGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5157039-A | Lipoxygenase inhibitors | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-10-20 | — | — | US | disclosed |
| US-5109009-A | QUINOLINE AND PYRIDINE COMPOUNDS AND INHIBITION OF 5-LIPOXYGENASES THEREWITH | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1992-04-28 | — | — | US | disclosed |
| US-4826987-A | Pyridyl and quinoline derivatives | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1989-05-02 | — | — | US | disclosed |