Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7089136 | 0.79 | HSD17B10 (0.46) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL15698069 | 0.79 | HSP90AB1 (0.42) | ALDH1A1L3MBTL1HMGCRLMNAHTT | |
| SCHEMBL9720570 | 0.79 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1HMGCRLMNAHTT | |
| SCHEMBL29173808 | 0.78 | KDM4E (0.46) | ALDH1A1KDM4EMAPTHSD17B10GAA | |
| SCHEMBL9720581 | 0.76 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1HMGCRLMNAHTT | |
| SCHEMBL9720532 | 0.76 | ALDH1A1 (0.61) | ALDH1A1L3MBTL1HMGCRKDM4EMEN1 | |
| SCHEMBL7193425 | 0.76 | CYP3A4 (0.44) | ALDH1A1L3MBTL1HMGCRLMNAHTT | |
| SCHEMBL9720594 | 0.75 | L3MBTL1 (0.50) | ALDH1A1L3MBTL1HMGCRLMNAHTT | |
| SCHEMBL9720676 | 0.74 | HMGCR (0.58) | ALDH1A1L3MBTL1HMGCRHTTKDM4E | |
| SCHEMBL11121533 | 0.74 | L3MBTL1 (0.43) | ALDH1A1L3MBTL1LMNAHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5103022-A | Reacting dl-2-methyl-1-(4-trifluoromethylphenyl)-3-pyrrolidino -1-propanone with l-acetylphenylglycine to form corresponding diastereomeric salt, deposition, isolation of l-2-methyl-1-(4-trifluoromethylphenyl)-3-pyrrolidino-1-propanone | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1992-04-07 | — | — | US | disclosed |
| US-5057535-A | Muscle relaxants | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1991-10-15 | — | — | US | disclosed |
| EP-0200942-A2 | New derivatives of an aminoketone | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1986-11-12 | — | — | EP | disclosed |