SCHEMBL9720698

SCHEMBL9720698

CCCNCc1nc(-c2ccc(C)cc2)[nH]c1C

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GRIN2B Q13224 2/20 0.41
VSIR Q9H7M9 1/20 0.36
SMPD3 Q9NY59 1/20 0.36
EGFR P00533 1/20 0.36
TNKS O95271 2/20 0.35
PARP1 P09874 2/20 0.35
TNKS2 Q9H2K2 2/20 0.35
TP53 P04637 1/20 0.35
CTSS P25774 1/20 0.35
SSTR3 P32745 1/20 0.34
RAB9A P51151 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
HPSE Q9Y251 1/20 0.34
DRD2 P14416 1/20 0.34
DRD4 P21917 1/20 0.34
DRD3 P35462 1/20 0.34
DCUN1D1 Q96GG9 1/20 0.33
NPBWR1 P48145 1/20 0.33
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9720791 0.92 SMPD3 (0.40) GRIN2BVSIRSMPD3EGFRTNKS
SCHEMBL9720663 0.89 HRH4 (0.44) GRIN2BVSIRSMPD3EGFRSMN1; SMN2
SCHEMBL9720766 0.82 SMN1; SMN2 (0.45) VSIRTNKSPARP1TNKS2SSTR3
SCHEMBL9720872 0.80 VSIR (0.45) VSIRTNKSPARP1TNKS2RAB9A
SCHEMBL9720685 0.78 KDM4E (0.39) GRIN2BEGFRTNKSPARP1TNKS2
SCHEMBL19350091 0.74 CTSS (0.41) EGFRTNKSPARP1TNKS2CTSS
SCHEMBL6649887 0.74 TNKS (0.41) SMPD3TNKSPARP1TNKS2CTSS
SCHEMBL9720797 0.73 GRIN2B (0.51) GRIN2BCTSSRAB9AMAPT
Hydrochloric Acid SCHEMBL8963760 0.73 CTSS (0.40) EGFRTNKSPARP1TNKS2CTSS
Hydrochloric Acid SCHEMBL1437155 0.73 SMPD3 (0.40) SMPD3TNKSPARP1TNKS2CTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5142052-A Cationic effect-driven carbinol/amine reaction LABORATOIRES SYNTEX (FR) 1992-08-25 US disclosed