Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | COMT | P21964 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14417383 | 0.89 | MCL1 (0.49) | MCL1TLR8CNR1CNR2HSD17B1 | |
| SCHEMBL14417224 | 0.87 | IDO1 (0.48) | MCL1TLR8CNR1CNR2HSD17B1 | |
| SCHEMBL9721339 | 0.87 | TLR8 (0.51) | TLR8HSD17B1HSD17B2APPESR2 | |
| SCHEMBL9721390 | 0.85 | TLR8 (0.43) | TLR8HSD17B1HSD17B2APPESR2 | |
| SCHEMBL16852435 | 0.78 | MCL1 (0.49) | MCL1TLR8CNR1CNR2HSD17B1 | |
| SCHEMBL29819560 | 0.78 | MCL1 (0.56) | MCL1TLR8CNR1CNR2HSD17B1 | |
| SCHEMBL30668980 | 0.78 | MCL1 (0.56) | MCL1TLR8CNR1CNR2HSD17B1 | |
| SCHEMBL9721286 | 0.77 | APP (0.60) | APPMAPT | |
| SCHEMBL23496970 | 0.77 | TLR8 (0.57) | MCL1TLR8HSD17B1HSD17B2APP | |
| SCHEMBL30719600 | 0.77 | TLR8 (0.57) | MCL1TLR8HSD17B1HSD17B2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | claimed |
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | disclosed |
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | disclosed |