Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SNCA | P37840 | 4/20 | 0.47 |
| ▸ | QDPR | P09417 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721390 | 0.82 | TLR8 (0.43) | APPMAPT | |
| SCHEMBL9721339 | 0.80 | TLR8 (0.51) | APPMAPT | |
| SCHEMBL172070 | 0.77 | APP (0.68) | APPALOX5MAPTSNCAQDPR | |
| SCHEMBL9721283 | 0.77 | MCL1 (0.47) | APPMAPT | |
| SCHEMBL7738889 | 0.76 | ALOX5 (0.62) | APPALOX5MAPTSNCAMIF | |
| SCHEMBL338028 | 0.76 | APP (1.00) | APPALOX5MAPTSNCAQDPR | |
| SCHEMBL9721256 | 0.74 | APP (0.47) | APPALOX5MAPTSNCAQDPR | |
| Iodide SCHEMBL28785231 | 0.73 | — | — | |
| SCHEMBL25420746 | 0.73 | APP (0.56) | APPALOX5MAPTSNCAQDPR | |
| SCHEMBL5685022 | 0.73 | APP (0.56) | APPALOX5MAPTSNCAQDPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | claimed |
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | claimed |
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | disclosed |
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | disclosed |