Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 6/20 | 0.49 |
| ▸ | HSD17B2 | P37059 | 6/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721390 | 0.91 | TLR8 (0.43) | TLR8HSD17B1HSD17B2CYP3A4CYP2D6 | |
| SCHEMBL9721283 | 0.87 | MCL1 (0.47) | TLR8HSD17B1HSD17B2MAPTESR2 | |
| SCHEMBL10454881 | 0.84 | TLR8 (0.44) | TLR8HSD17B1HSD17B2KDM4EALDH1A1 | |
| SCHEMBL23496970 | 0.83 | TLR8 (0.57) | TLR8HSD17B1HSD17B2CYP3A4CYP2D6 | |
| SCHEMBL30719600 | 0.83 | TLR8 (0.57) | TLR8HSD17B1HSD17B2CYP3A4CYP2D6 | |
| SCHEMBL9721286 | 0.80 | APP (0.60) | MAPTAPP | |
| SCHEMBL13678995 | 0.79 | TLR8 (0.70) | TLR8HSD17B1HSD17B2CYP3A4CYP2D6 | |
| SCHEMBL14417383 | 0.76 | MCL1 (0.49) | TLR8HSD17B1HSD17B2MAPTESR2 | |
| SCHEMBL9721275 | 0.75 | TLR8 (0.40) | TLR8HSD17B1HSD17B2CYP3A4CYP2D6 | |
| SCHEMBL272034 | 0.75 | HSD17B1 (0.68) | HSD17B1HSD17B2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | claimed |
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | disclosed |
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | disclosed |