Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | BCL2 | P10415 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721287 | 0.91 | AKR1B1 (0.40) | CYP3A4AKR1B1MCL1MAPTBCL2 | |
| SCHEMBL9721310 | 0.84 | CYP3A4 (0.35) | CYP3A4AKR1B1MCL1MAPTBCL2 | |
| SCHEMBL9721322 | 0.82 | CYP3A4 (0.40) | CYP3A4AKR1B1MCL1MAPTBCL2 | |
| SCHEMBL9721312 | 0.80 | MAPK8 (0.34) | CYP3A4AKR1B1MCL1MAPTBCL2 | |
| SCHEMBL10454966 | 0.73 | CYP3A4 (0.35) | CYP3A4AKR1B1MCL1MAPTBCL2 | |
| SCHEMBL9721316 | 0.69 | ERN1 (0.39) | CYP3A4AKR1B1MCL1MAPTBCL2 | |
| SCHEMBL9721281 | 0.68 | CA1 (0.37) | LDHALDHB | |
| SCHEMBL9721255 | 0.66 | ERN1 (0.39) | CYP3A4AKR1B1MCL1MAPTBCL2 | |
| SCHEMBL9721314 | 0.66 | ERN1 (0.39) | CYP3A4AKR1B1MCL1MAPTBCL2 | |
| SCHEMBL10895048 | 0.65 | CYP3A4 (0.53) | CYP3A4MAPTUSP2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | claimed |