Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 4/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | BCL2 | P10415 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9721314 | 0.91 | ERN1 (0.39) | ERN1MCL1AKR1B1BCL2L1MAPT | |
| SCHEMBL9721255 | 0.87 | ERN1 (0.39) | ERN1MCL1AKR1B1BCL2L1MAPT | |
| SCHEMBL9721268 | 0.83 | NOX4 (0.42) | ERN1MAPTCYP3A4KDM4EMEN1 | |
| SCHEMBL9721269 | 0.77 | SENP1 (0.36) | MCL1BCL2L1MAPTBCL2CYP3A4 | |
| SCHEMBL9721289 | 0.72 | ALB (0.49) | ERN1MAPTALDH1A1LDHATP53 | |
| SCHEMBL10453709 | 0.70 | TSHR (0.35) | MAPTCYP3A4KDM4EALDH1A1LMNA | |
| SCHEMBL9721380 | 0.69 | CYP3A4 (0.39) | ERN1MCL1AKR1B1BCL2L1MAPT | |
| SCHEMBL9721292 | 0.68 | HSD17B1 (0.41) | MCL1BCL2L1MAPTBCL2CYP3A4 | |
| SCHEMBL9721276 | 0.68 | ESR1 (0.44) | ERN1MAPTCYP3A4KDM4EMEN1 | |
| SCHEMBL9721310 | 0.68 | CYP3A4 (0.35) | ERN1MCL1AKR1B1BCL2L1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | claimed |
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | claimed |
| US-5112869-A | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1992-05-12 | — | — | US | disclosed |
| WO-1990011988-A1 | SUBSTITUTED 1-PHENYLNAPHTHALENES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-18 | — | — | WO | disclosed |