Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9425432 | 0.86 | ALDH1A1 (0.45) | ALDH1A1MAPTKDM4EGAALMNA | |
| Hydrochloric Acid SCHEMBL9426498 | 0.85 | ALDH1A1 (0.44) | ALDH1A1MAPTKDM4EGAALMNA | |
| SCHEMBL18858122 | 0.79 | KDM4E (0.39) | ALDH1A1MAPTKDM4EGLAGAA | |
| SCHEMBL2046959 | 0.75 | — | — | |
| SCHEMBL30074192 | 0.75 | — | — | |
| SCHEMBL9426430 | 0.75 | KDM4E (0.50) | ALDH1A1MAPTKDM4EGLAGAA | |
| SCHEMBL13568860 | 0.74 | HDAC3 (0.47) | ALDH1A1MAPTKDM4EGAAHDAC3 | |
| Hydrochloric Acid SCHEMBL27703391 | 0.74 | AOC1 (0.53) | ALDH1A1MAPTKDM4EGLAGAA | |
| SCHEMBL28824138 | 0.73 | KDM4E (0.53) | ALDH1A1MAPTKDM4EGLAGAA | |
| SCHEMBL15432244 | 0.72 | KDM4E (0.56) | ALDH1A1MAPTKDM4EGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111205310-B | Heterocyclic fused pyrimidine derivative, pharmaceutical composition and application thereof | 上海迪诺医药科技有限公司 | 2023-12-19 | — | — | CN | disclosed |
| CN-111205310-A | Heterocyclic fused pyrimidine derivative, and pharmaceutical composition and application thereof | 上海迪诺医药科技有限公司 | 2020-05-29 | — | — | CN | disclosed |
| US-5137896-A | Useful in treatment of gastrointestinal and psychic disorder; analgesic, antiemetic and antiulcer agent | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-11 | — | — | US | disclosed |
| US-5057525-A | Stimulators of gastrointestinal motility | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-10-15 | — | — | US | disclosed |
| US-4962115-A | Stimulate motility of gastrointestinal system | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-10-09 | — | — | US | disclosed |
| EP-0076530-B1 | NOVEL N-(3-HYDROXY-4-PIPERIDINYL)BENZAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-12-11 | — | — | EP | disclosed |
| EP-0076530-A2 | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-04-13 | — | — | EP | disclosed |