Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC5R | P33032 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | MC1R | Q01726 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.47 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30029284 | 1.00 | MC5R (0.61) | MC5RMAPK1LMNANR1I2ADRA2A | |
| SCHEMBL4159646 | 0.87 | HTR2A (0.56) | MC5RMAPK1LMNANR1I2ADRA2A | |
| SCHEMBL6858815 | 0.84 | LMNA (0.56) | MC5RMAPK1LMNANR1I2ADRA2A | |
| SCHEMBL30482193 | 0.82 | MC5R (0.70) | MC5RMAPK1CYP2D6KMT2AMEN1 | |
| SCHEMBL2865597 | 0.82 | MC5R (0.70) | MC5RMAPK1CYP2D6KMT2AMEN1 | |
| SCHEMBL4159641 | 0.80 | KMT2A (0.69) | LMNANR1I2ADRA2ACYP2D6ACHE | |
| SCHEMBL6008064 | 0.80 | MC5R (0.70) | MC5RMAPK1CYP2D6KMT2AMEN1 | |
| SCHEMBL3242373 | 0.80 | MC5R (0.67) | MC5RMAPK1LMNACYP2D6KMT2A | |
| SCHEMBL15130991 | 0.80 | MC5R (0.67) | MC5RMAPK1LMNAKMT2AMEN1 | |
| SCHEMBL21296202 | 0.80 | MC5R (0.67) | MC5RMAPK1KMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403485-A | Butenafine intermediate compound | 山东新时代药业有限公司 | 2022-11-29 | — | — | CN | claimed |
| CN-113493385-A | Method for synthesizing butenafine hydrochloride | 鲁南制药集团股份有限公司 | 2021-10-12 | — | — | CN | claimed |
| EP-0310122-B1 | ANTIFUNGAL COMPOSITION | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1991-07-24 | — | — | EP | claimed |
| EP-0310122-A1 | Antifungal composition | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1989-04-05 | — | — | EP | claimed |
| JP-63277650-A | — | — | None | — | — | JP | disclosed |
| CN-113493385-B | Method for synthesizing butenafine hydrochloride | 鲁南制药集团股份有限公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-113493385-B | Method for synthesizing butenafine hydrochloride | 鲁南制药集团股份有限公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-115403485-A | Butenafine intermediate compound | 山东新时代药业有限公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-115403485-A | Butenafine intermediate compound | 山东新时代药业有限公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-113493385-A | Method for synthesizing butenafine hydrochloride | 鲁南制药集团股份有限公司 | 2021-10-12 | — | — | CN | disclosed |
| CN-113493385-A | Method for synthesizing butenafine hydrochloride | 鲁南制药集团股份有限公司 | 2021-10-12 | — | — | CN | disclosed |
| EP-3765004-A1 | ANTIFUNGAL SOLUTION AND FOOT WIPE | Pell Skin Co., LLC (US) | 2021-01-20 | — | — | EP | disclosed |
| WO-2019178366-A1 | ANTIFUNGAL SOLUTION AND FOOT WIPE | PELLI SKIN CO., LLC (US) | 2019-09-19 | — | — | WO | disclosed |
| CN-105130823-B | A kind of method of synthesis butenafine | 中国科学技术大学 | 2017-03-01 | — | — | CN | disclosed |
| US-5120735-A | Synergistic mixture of miconazole, ketoconazole or fluconazole and N-4-tertbutylbenzyl-N-methyl-1-naphthalenemethylamine | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1992-06-09 | — | — | US | disclosed |
| EP-0310122-B1 | ANTIFUNGAL COMPOSITION | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1991-07-24 | — | — | EP | disclosed |
| EP-0221781-B1 | BENZYLAMINE DERIVATIVES, PROCESS FOR PRODUCTION THEREOF, AND USE THEREOF | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-05-02 | — | — | EP | disclosed |
| US-4822822-A | FUNGICIDES FOR PLANTS AND ANIMALS | MITSUI TOATSU CHEMICALS, INC. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0310122-A1 | Antifungal composition | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1989-04-05 | — | — | EP | disclosed |
| JP-S63277650-A | TERTIARY AMINE DERIVATIVE, PRODUCTION THEREOF AND GERMICIDE FOR FARE AND GARDEN | NISSAN CHEM IND LTD | 1988-11-15 | — | — | JP | disclosed |