SCHEMBL9722746

SCHEMBL9722746

O=C(COc1c(Cl)cc(Cl)cc1Cl)Nc1ncc(Cl)cn1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 7/20 0.49
NPC1 O15118 6/20 0.49
TP53 P04637 3/20 0.49
MAPT P10636 2/20 0.49
TSHR P16473 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
PKM P14618 2/20 0.49
HPGD P15428 2/20 0.49
MAPK1 P28482 1/20 0.49
NPSR1 Q6W5P4 1/20 0.48
L3MBTL1 Q9Y468 9/20 0.47
ALDH1A1 P00352 2/20 0.47
TDP1 Q9NUW8 2/20 0.44
LMNA P02545 1/20 0.43
NFKB1 P19838 1/20 0.43
NFKB2 Q00653 1/20 0.43
RELA Q04206 1/20 0.43
POLB P06746 2/20 0.42
NR4A1 P22736 1/20 0.41
GAA P10253 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9722679 0.81 RAB9A (0.74) RAB9ANPC1TP53MAPTTSHR
SCHEMBL9722721 0.79 MEN1 (0.57) MAPTSMN1; SMN2NPSR1ALDH1A1LMNA
SCHEMBL10733362 0.77 NOTUM (0.53) RAB9ANPC1TP53MAPTTSHR
SCHEMBL5640127 0.77 LMNA (0.67) NPC1MAPTHPGDMAPK1ALDH1A1
SCHEMBL11869391 0.76 OGG1 (0.53) MAPTTSHRSMN1; SMN2HPGDL3MBTL1
SCHEMBL10729084 0.75 NOTUM (0.68) RAB9ANPC1MAPTALDH1A1TDP1
SCHEMBL25333664 0.75 KDM4E (0.44) RAB9ANPC1MAPTTSHRSMN1; SMN2
SCHEMBL9722686 0.74 RAB9A (0.73) RAB9ANPC1TP53MAPTTSHR
SCHEMBL10726989 0.74 NPSR1 (0.64) RAB9ANPC1TP53MAPTPKM
SCHEMBL10387979 0.73 HPGD (0.56) RAB9ANPC1MAPTTSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5139564-A Applying postemergence PARK SANG W (KR) 1992-08-18 US disclosed