SCHEMBL9722767

SCHEMBL9722767

Nc1nc2ccc(C(=O)OCCO)cc2s1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 3/20 0.53
PIK3CD O00329 1/20 0.52
PIK3CA P42336 1/20 0.52
PIK3CB P42338 1/20 0.52
PI4KA P42356 1/20 0.52
PIK3CG P48736 1/20 0.52
PI4KB Q9UBF8 1/20 0.52
CYP3A4 P08684 4/20 0.52
NPC1 O15118 4/20 0.52
RAB9A P51151 4/20 0.52
SMN1; SMN2 Q16637 3/20 0.52
MAPT P10636 1/20 0.52
ALDH1A1 P00352 2/20 0.51
CYP2D6 P10635 2/20 0.51
LMNA P02545 2/20 0.51
KCNH2 Q12809 1/20 0.50
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
CYP1A2 P05177 1/20 0.49
CYP2C19 P33261 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9722789 0.92 CYP2C9 (0.51) CYP2C9PIK3CDPIK3CAPIK3CBPI4KA
SCHEMBL9722853 0.88 NPC1 (0.57) CYP2C9CYP3A4NPC1RAB9ASMN1; SMN2
SCHEMBL9722788 0.87 CYP2C9 (0.60) CYP2C9PIK3CDPIK3CAPIK3CBPI4KA
SCHEMBL11439414 0.87 CYP2C9 (0.54) CYP2C9PIK3CAPIK3CBPIK3CGPI4KB
SCHEMBL9722808 0.86 NPC1 (0.55) CYP2C9CYP3A4NPC1RAB9ASMN1; SMN2
SCHEMBL73574 0.85 RAB9A (0.65) CYP2C9CYP3A4NPC1RAB9ASMN1; SMN2
SCHEMBL9722769 0.85 CYP2C9 (0.57) CYP2C9CYP3A4NPC1RAB9ASMN1; SMN2
SCHEMBL11833323 0.85 PHLPP2 (0.56) CYP2C9CYP3A4NPC1RAB9ASMN1; SMN2
SCHEMBL21186386 0.81 CYP2D6 (0.63) CYP2C9CYP3A4NPC1RAB9ASMN1; SMN2
SCHEMBL9722781 0.81 CYP2C9 (0.53) CYP2C9CYP3A4NPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5120872-A Textile dyeing CIBA-GEIGY CORPORATION (US) 1992-06-09 US disclosed
US-4994563-A Dyeing, printing cellulose, silk, wool, synthetic polyamides; colorfastness CIBA-GEIGY CORPORATION (US) 1991-02-19 US disclosed
EP-0349486-A2 Azo dyes, their preparation and their use CIBA-GEIGY AG (CH) 1990-01-03 EP disclosed