Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 2/20 | 0.33 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.33 |
| ▸ | SLC6A2 known ✓ | P23975 | 4/20 | 0.32 |
| ▸ | SLC6A4 known ✓ | P31645 | 4/20 | 0.32 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.31 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 4/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9466647 | 0.80 | HTR2A (0.36) | CARM1PRMT6PRMT8SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL9523462 | 0.80 | ADRA2A (0.39) | CARM1PRMT6TAAR1SLC6A2SLC6A4 | |
| Bromide SCHEMBL9722855 | 0.75 | SLC6A2 (0.38) | SLC6A2SLC6A4ADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL9521304 | 0.72 | STS (0.40) | CARM1PRMT6PRMT8SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL9521607 | 0.70 | KMT2A (0.42) | CARM1PRMT6PRMT8TAAR1SLC6A2 | |
| Bromide SCHEMBL9464934 | 0.69 | SLC6A4 (0.50) | TAAR1SLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL9715577 | 0.66 | HTR1A (0.48) | CARM1SLC6A4 | |
| Hydrochloric Acid SCHEMBL9520952 | 0.65 | HTR1A (0.42) | CARM1PRMT6PRMT8LMNASLC6A4 | |
| Hydrochloric Acid SCHEMBL9464705 | 0.64 | HTR1A (0.39) | TAAR1ALDH1A1SLC6A4 | |
| SCHEMBL25046506 | 0.64 | TAAR1 (0.53) | CARM1TAAR1ADRB1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140039-A | Antidepressants, metabolic disorders | ABBOTT LABORATORIES (US) | 1992-08-18 | — | — | US | disclosed |
| EP-0325964-A1 | Aminomethyl-chroman and -thiochroman compounds | ABBOTT LABORATORIES (US) | 1989-08-02 | — | — | EP | disclosed |