Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 18/20 | 0.38 |
| ▸ | SLC6A4 known ✓ | P31645 | 18/20 | 0.38 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.33 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9466639 | 0.80 | HTR2C (0.37) | SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL9523455 | 0.80 | ADRA2A (0.44) | SLC6A2SLC6A4ADRA2AADRA2BADRA2C | |
| Bromide SCHEMBL9722858 | 0.75 | CARM1 (0.34) | SLC6A2SLC6A4ADRA2AADRA2BADRA2C | |
| SCHEMBL9531879 | 0.74 | KDM4C (0.39) | SLC6A2SLC6A4 | |
| Bromide SCHEMBL9521066 | 0.73 | SLC6A2 (0.38) | SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL9521298 | 0.71 | ESR1 (0.46) | SLC6A2SLC6A4 | |
| Bromide SCHEMBL9464934 | 0.70 | SLC6A4 (0.50) | SLC6A4ADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL9521602 | 0.70 | SLC6A2 (0.45) | SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL9464556 | 0.68 | HTR1A (0.36) | SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL9523530 | 0.66 | HTR6 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140039-A | Antidepressants, metabolic disorders | ABBOTT LABORATORIES (US) | 1992-08-18 | — | — | US | disclosed |
| EP-0325964-A1 | Aminomethyl-chroman and -thiochroman compounds | ABBOTT LABORATORIES (US) | 1989-08-02 | — | — | EP | disclosed |