Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10976047 | 1.00 | THRB (0.39) | THRBCYP2C9GRM2GRM3ALDH1A1 | |
| Carbamic Acid SCHEMBL27703081 | 0.79 | THRB (0.39) | THRBCYP2C9GRM2GRM3ALDH1A1 | |
| SCHEMBL4990698 | 0.78 | THRB (0.38) | THRBCYP2C9ALDH1A1HTTEPHX1 | |
| SCHEMBL2190387 | 0.75 | THRB (0.35) | THRBCYP2C9GRM2GRM3ALDH1A1 | |
| SCHEMBL2194685 | 0.75 | THRB (0.35) | THRBCYP2C9GRM2GRM3ALDH1A1 | |
| Acetic Acid SCHEMBL700515 | 0.74 | THRB (0.42) | THRBCYP2C9ALDH1A1HTTEPHX1 | |
| SCHEMBL6865794 | 0.73 | THRB (0.40) | THRBCYP2C9GRM2GRM3ALDH1A1 | |
| SCHEMBL11633433 | 0.72 | KMT2A (0.36) | THRBALDH1A1HTTLMNATSHR | |
| SCHEMBL7715121 | 0.72 | ALDH1A1 (0.40) | THRBCYP2C9ALDH1A1HTTEPHX1 | |
| SCHEMBL299469 | 0.72 | GRIN2D (0.41) | THRBALDH1A1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134121-A | Blocking peptides; therapy for nervous sytem disorders | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1992-07-28 | — | — | US | disclosed |
| WO-1989009225-A1 | NERVE GROWTH FACTOR PEPTIDES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1989-10-05 | — | — | WO | disclosed |
| EP-0335637-A2 | Nerve growth factor peptides | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1989-10-04 | — | — | EP | disclosed |