Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.55 |
| ▸ | TERT | O14746 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7699246 | 0.84 | KDM4E (0.49) | KDM4ELMNADOT1LTERTGAA | |
| SCHEMBL4219099 | 0.84 | LMNA (0.61) | KDM4ELMNADOT1LGAAKCNH2 | |
| SCHEMBL11039427 | 0.82 | CRHR1 (0.52) | LMNADOT1LTERTKCNH2MAPT | |
| SCHEMBL9381975 | 0.82 | BACE1 (0.49) | KDM4ELMNAGAAKMT2AMEN1 | |
| SCHEMBL5848248 | 0.82 | DOT1L (0.52) | KDM4ELMNADOT1LTERTGAA | |
| SCHEMBL2534913 | 0.82 | LMNA (0.50) | KDM4ELMNADOT1LGAAKMT2A | |
| SCHEMBL19689623 | 0.82 | ESR1 (0.49) | KDM4ELMNADOT1LGAAKCNH2 | |
| SCHEMBL24003870 | 0.80 | DOT1L (0.50) | KDM4EDOT1LTERTGAAL3MBTL1 | |
| SCHEMBL29324282 | 0.80 | DOT1L (0.53) | KDM4ELMNADOT1LTERTGAA | |
| SCHEMBL266444 | 0.79 | LMNA (0.64) | KDM4ELMNADOT1LGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112837-A | Inhibitors of thymidylate synthetase enzyme | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-05-12 | — | — | US | disclosed |
| EP-0318225-A2 | 6-Aryl aminomethyl quinoline derivatives and their use as anti-tumour agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-31 | — | — | EP | disclosed |