Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.53 |
| ▸ | TERT | O14746 | 2/20 | 0.51 |
| ▸ | GAK | O14976 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.44 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29324280 | 0.80 | CYP1A2 (0.58) | TERTGAKPOLBRAD52MEN1 | |
| SCHEMBL9724306 | 0.80 | KDM4E (0.59) | DOT1LTERTPOLBRAD52PTPN11 | |
| SCHEMBL29324265 | 0.77 | CYP1A2 (0.42) | GAKPOLBRAD52MEN1KMT2A | |
| SCHEMBL11039427 | 0.77 | CRHR1 (0.52) | DOT1LTERTPOLBKCNH2LMNA | |
| SCHEMBL5848248 | 0.77 | DOT1L (0.52) | DOT1LTERTPOLBPTPN11MEN1 | |
| SCHEMBL24003870 | 0.74 | DOT1L (0.50) | DOT1LTERTPTPN11MEN1KMT2A | |
| SCHEMBL266444 | 0.74 | LMNA (0.64) | DOT1LPOLBPTPN11MEN1KMT2A | |
| SCHEMBL29877118 | 0.74 | LMNA (0.64) | DOT1LPOLBPTPN11MEN1KMT2A | |
| SCHEMBL30251742 | 0.73 | CA12 (0.53) | DOT1LTERTPOLBKCNH2LMNA | |
| SCHEMBL23858484 | 0.73 | CA12 (0.53) | DOT1LTERTPOLBKCNH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228484-A1 | MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2024-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228484-A1 | MONOACYLGLYCEROL LIPASE MODULATORS | MGLL, LPL, PNLIP | DOT1L 2830/4885TERT 2055/4885GAK 2722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.