Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.87 |
| ▸ | DRD3 | P35462 | 8/20 | 0.62 |
| ▸ | HTR2A | P28223 | 5/20 | 0.62 |
| ▸ | DRD2 | P14416 | 6/20 | 0.60 |
| ▸ | DRD4 | P21917 | 4/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.60 |
| ▸ | CCR3 | P51677 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9725005 | 0.93 | HTR1A (1.00) | HTR1ADRD3HTR2ADRD2DRD4 | |
| SCHEMBL9725016 | 0.92 | HTR1A (0.73) | HTR1ADRD3HTR2ADRD2DRD4 | |
| SCHEMBL9725045 | 0.85 | HTR1A (0.84) | HTR1ADRD3HTR2ADRD2DRD4 | |
| SCHEMBL14761668 | 0.82 | HTR1A (0.70) | HTR1ADRD3HTR2ADRD2DRD4 | |
| SCHEMBL14761321 | 0.81 | DRD3 (0.77) | HTR1ADRD3HTR2ADRD2DRD4 | |
| SCHEMBL9725055 | 0.80 | HTR1A (0.64) | HTR1ADRD3HTR2ADRD2DRD4 | |
| SCHEMBL27726458 | 0.78 | HTR1A (0.73) | HTR1ADRD3HTR2ADRD2DRD4 | |
| SCHEMBL9725026 | 0.78 | HTR1A (0.70) | HTR1ADRD3HTR2ADRD2DRD4 | |
| SCHEMBL14761844 | 0.77 | DRD3 (0.72) | HTR1ADRD3HTR2ADRD2DRD4 | |
| SCHEMBL9725141 | 0.77 | HTR1A (0.66) | HTR1ADRD3HTR2ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135931-A | Antidepressants, psychological disorders, nervous system disorders | AKZO N.V. (NL) | 1992-08-04 | — | — | US | disclosed |
| EP-0462638-A1 | Pyridinylpiperazine derivatives | Akzo Nobel N.V. (NL) | 1991-12-27 | — | — | EP | disclosed |