Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.73 |
| ▸ | DRD3 | P35462 | 13/20 | 0.73 |
| ▸ | HTR2A | P28223 | 5/20 | 0.73 |
| ▸ | DRD2 | P14416 | 10/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | DRD4 | P21917 | 2/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9725045 | 0.93 | HTR1A (0.84) | HTR1ADRD3HTR2ADRD2HTR2C | |
| SCHEMBL9724927 | 0.92 | HTR1A (0.87) | HTR1ADRD3HTR2ADRD2HTR2C | |
| SCHEMBL14761321 | 0.86 | DRD3 (0.77) | HTR1ADRD3HTR2ADRD2HTR2C | |
| SCHEMBL9725005 | 0.84 | HTR1A (1.00) | HTR1ADRD3HTR2ADRD2DRD4 | |
| SCHEMBL4522254 | 0.84 | DRD3 (1.00) | HTR1ADRD3HTR2ADRD2HTR2C | |
| SCHEMBL14761844 | 0.83 | DRD3 (0.72) | HTR1ADRD3HTR2ADRD2HTR2C | |
| SCHEMBL4534941 | 0.82 | DRD3 (1.00) | HTR1ADRD3HTR2ADRD2HTR2C | |
| SCHEMBL27726458 | 0.80 | HTR1A (0.73) | HTR1ADRD3HTR2ADRD2HTR2C | |
| SCHEMBL7132544 | 0.80 | DRD2 (0.74) | HTR1ADRD3HTR2ADRD2HTR2C | |
| SCHEMBL14761918 | 0.78 | HTR1A (0.66) | HTR1ADRD3HTR2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135931-A | Antidepressants, psychological disorders, nervous system disorders | AKZO N.V. (NL) | 1992-08-04 | — | — | US | disclosed |
| EP-0462638-A1 | Pyridinylpiperazine derivatives | Akzo Nobel N.V. (NL) | 1991-12-27 | — | — | EP | disclosed |