Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | HTR1D | P28221 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9724927 | 0.93 | HTR1A (0.87) | HTR1ADRD2DRD4ADRA1AHTR2B | |
| SCHEMBL9725045 | 0.92 | HTR1A (0.84) | HTR1ADRD2DRD4HTR2BMAPT | |
| SCHEMBL9725016 | 0.84 | HTR1A (0.73) | HTR1ADRD2DRD4ADRA1AHTR2A | |
| SCHEMBL27726458 | 0.84 | HTR1A (0.73) | HTR1ADRD2DRD4HTR2BHTR2A | |
| SCHEMBL9725026 | 0.82 | HTR1A (0.70) | HTR1ADRD2DRD4HTR2BHTR2A | |
| SCHEMBL14761329 | 0.81 | HTR1A (0.67) | HTR1ADRD2DRD4CYP1A2CYP3A4 | |
| SCHEMBL9725141 | 0.80 | HTR1A (0.66) | HTR1ADRD2DRD4ADRA1AHTR2B | |
| SCHEMBL14761918 | 0.79 | HTR1A (0.66) | HTR1ADRD4MAPTHSD17B10HTR2A | |
| SCHEMBL9724944 | 0.78 | HTR1A (0.64) | HTR1ADRD2DRD4 | |
| SCHEMBL9725055 | 0.78 | HTR1A (0.64) | HTR1ADRD2DRD4HTR2BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135931-A | Antidepressants, psychological disorders, nervous system disorders | AKZO N.V. (NL) | 1992-08-04 | — | — | US | claimed |
| EP-0462638-A1 | Pyridinylpiperazine derivatives | Akzo Nobel N.V. (NL) | 1991-12-27 | — | — | EP | claimed |
| US-5135931-A | Antidepressants, psychological disorders, nervous system disorders | AKZO N.V. (NL) | 1992-08-04 | — | — | US | disclosed |
| EP-0462638-A1 | Pyridinylpiperazine derivatives | Akzo Nobel N.V. (NL) | 1991-12-27 | — | — | EP | disclosed |