Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.53 |
| ▸ | CTSD | P07339 | 1/20 | 0.51 |
| ▸ | CTSE | P14091 | 1/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9725825 | 0.89 | REN (0.53) | RENCTSDCTSE | |
| SCHEMBL9725812 | 0.89 | REN (0.53) | RENCTSDCTSE | |
| SCHEMBL9725818 | 0.89 | REN (0.53) | RENCTSDCTSE | |
| SCHEMBL9739264 | 0.89 | REN (0.53) | RENCTSDCTSE | |
| SCHEMBL9741114 | 0.85 | REN (0.49) | RENCTSDCTSE | |
| SCHEMBL9741069 | 0.83 | REN (0.47) | RENCTSDCTSE | |
| SCHEMBL9741074 | 0.83 | REN (0.47) | RENCTSDCTSE | |
| SCHEMBL7278377 | 0.82 | PSEN1 (0.46) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7278381 | 0.82 | PSEN1 (0.46) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9849721 | 0.82 | REN (0.48) | RENPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | disclosed |