Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAAT5 | Q96KN8 | 17/20 | 0.73 |
| ▸ | PLAAT4 | Q9UL19 | 17/20 | 0.73 |
| ▸ | PLAAT3 | P53816 | 16/20 | 0.67 |
| ▸ | PLAAT2 | Q9NWW9 | 16/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1093862 | 0.84 | HPGD (0.91) | HPGDHDAC3 | |
| SCHEMBL2187602 | 0.79 | HPGD (1.00) | HPGDHDAC3 | |
| Butylbenzyl SCHEMBL28335644 | 0.79 | HPGD (0.62) | HPGDCYP1A2CYP2C9CYP2C19HDAC3 | |
| SCHEMBL7326454 | 0.78 | PLAAT5 (0.82) | PLAAT5PLAAT4PLAAT3PLAAT2 | |
| SCHEMBL13287459 | 0.78 | HPGD (0.97) | HPGDHDAC3 | |
| SCHEMBL2770651 | 0.78 | PLAAT5 (0.79) | PLAAT5PLAAT4PLAAT3PLAAT2HDAC3 | |
| SCHEMBL2119439 | 0.78 | EPHX1 (0.59) | HPGD | |
| SCHEMBL5933901 | 0.78 | HPGD (0.97) | HPGDHDAC3 | |
| SCHEMBL24012925 | 0.78 | HPGD (0.60) | HPGDCYP1A2CYP2C9CYP2C19HDAC3 | |
| SCHEMBL2770463 | 0.77 | PLAAT5 (0.80) | PLAAT5PLAAT4PLAAT3PLAAT2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098892-A | Angiotensin converting enzyme inhibitors as hypotensive agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-03-24 | — | — | US | disclosed |
| US-4822818-A | ANTIHYPERTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| US-4474692-A | L-Alanyl-N-(indan-2-yl)glycine, its esters and salts thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1984-10-02 | — | — | US | disclosed |
| EP-0051391-B1 | BICYCLIC COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1984-09-05 | — | — | EP | disclosed |
| EP-0051391-A1 | Bicyclic compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1982-05-12 | — | — | EP | disclosed |