Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAAT5 | Q96KN8 | 14/20 | 0.82 |
| ▸ | PLAAT4 | Q9UL19 | 14/20 | 0.82 |
| ▸ | PLAAT3 | P53816 | 13/20 | 0.82 |
| ▸ | PLAAT2 | Q9NWW9 | 13/20 | 0.82 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3056874 | 0.82 | KMT2A (0.71) | EPHX1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL30562867 | 0.81 | HPGD (0.74) | PLAAT5PLAAT4PLAAT3PLAAT2SMN1; SMN2 | |
| SCHEMBL1661081 | 0.81 | TRPV1 (0.76) | GAATRPV1ALDH1A1 | |
| SCHEMBL23805174 | 0.80 | PLAAT5 (0.56) | PLAAT5PLAAT4PLAAT3PLAAT2GAA | |
| SCHEMBL4279627 | 0.80 | KEAP1 (0.73) | PLAAT5PLAAT4SMN1; SMN2ALDH1A1 | |
| SCHEMBL20673342 | 0.79 | SMN1; SMN2 (0.81) | PLAAT5PLAAT4PLAAT3PLAAT2EPHX1 | |
| SCHEMBL20924992 | 0.79 | GAA (0.61) | PLAAT5PLAAT4PLAAT3PLAAT2GAA | |
| SCHEMBL24276173 | 0.79 | ALDH1A1 (0.59) | PLAAT5PLAAT4PLAAT3PLAAT2SMN1; SMN2 | |
| SCHEMBL19465026 | 0.79 | PLAAT5 (0.66) | PLAAT5PLAAT4PLAAT3PLAAT2ALDH1A1 | |
| SCHEMBL9725982 | 0.78 | PLAAT5 (0.73) | PLAAT5PLAAT4PLAAT3PLAAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4472380-A | CARBOXYALKYL DIPEPTIDE DERIVATIVES | MERCK & CO., INC. (US) | 1984-09-18 | — | — | US | disclosed |
| US-4374829-A | Aminoacid derivatives as antihypertensives | MERCK & CO., INC. (US) | 1983-02-22 | — | — | US | disclosed |
| EP-0012401-A1 | Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1980-06-25 | — | — | EP | disclosed |