Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | NOS3 | P29474 | 3/20 | 0.47 |
| ▸ | NOS1 | P29475 | 3/20 | 0.47 |
| ▸ | NOS2 | P35228 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 11/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29890904 | 0.82 | CYP11B2 (0.48) | MKNK1MKNK2DYRK1ADYRK2DYRK1B | |
| SCHEMBL580847 | 0.82 | CYP11B2 (0.48) | MKNK1MKNK2DYRK1ADYRK2DYRK1B | |
| SCHEMBL7774199 | 0.81 | MKNK2 (0.47) | MKNK1MKNK2DYRK1APRMT5WDR77 | |
| SCHEMBL3363667 | 0.80 | CTSD (0.53) | NOS3NOS1NOS2KDM4EMEN1 | |
| SCHEMBL11624257 | 0.79 | MAP4K4 (0.69) | MKNK1MKNK2MEN1AKT1PRMT5 | |
| SCHEMBL558935 | 0.78 | ALOX5AP (0.55) | NOS3NOS1NOS2DYRK1ADYRK2 | |
| SCHEMBL945362 | 0.77 | MKNK1 (0.63) | MKNK1MKNK2PRMT5WDR77PIM1 | |
| SCHEMBL15730772 | 0.76 | MKNK1 (0.50) | MKNK1MKNK2PRMT5WDR77MAP4K4 | |
| SCHEMBL13368032 | 0.76 | MKNK1 (0.62) | MKNK1MKNK2NOS3NOS1NOS2 | |
| SCHEMBL15730148 | 0.75 | MKNK1 (0.57) | MKNK1MKNK2NOS3NOS2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868177-B2 | Multi-cyclic compounds and method of use | AMGEN INC. (US) | 2011-01-11 | — | — | US | disclosed |
| US-20070213325-A1 | Multi-cyclic compound and method of use | AMGEN INC. (US) | 2007-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070213325-A1 | Multi-cyclic compound and method of use | TIE1, CDK1, CCNB1 | MKNK1 136/4885MKNK2 147/4885NOS3 871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.