Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 6/20 | 0.55 |
| ▸ | METAP2 | P50579 | 7/20 | 0.44 |
| ▸ | METAP1 | P53582 | 5/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726151 | 0.79 | REN (0.48) | REN | |
| SCHEMBL9260290 | 0.79 | REN (0.50) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL7290532 | 0.78 | REN (0.49) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL9726123 | 0.78 | REN (0.60) | RENMETAP2METAP1EPHX1CPB2 | |
| SCHEMBL7441065 | 0.77 | REN (0.69) | RENMETAP2EPHX1ALDH1A1KMT2A | |
| SCHEMBL7436027 | 0.76 | REN (0.52) | RENMETAP2METAP1CPB2 | |
| SCHEMBL7433023 | 0.75 | REN (0.47) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL8826686 | 0.74 | REN (0.56) | RENMETAP2METAP1EPHX1CPB2 | |
| SCHEMBL9727598 | 0.74 | REN (0.47) | RENMETAP2METAP1ALDH1A1KMT2A | |
| SCHEMBL9727591 | 0.74 | REN (0.47) | RENMETAP2METAP1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5147857-A | Enzyme inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1992-09-15 | — | — | US | disclosed |