Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 8/20 | 0.62 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | APLNR | P35414 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 6/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726419 | 0.88 | PDE9A (0.61) | PDE9AKDM4CNPC1PKMRAB9A | |
| SCHEMBL10601720 | 0.88 | PDE9A (0.61) | PDE9AKDM4CNPC1PKMRAB9A | |
| SCHEMBL9726712 | 0.87 | PDE9A (0.60) | PDE9AKDM4CNPC1PKMRAB9A | |
| SCHEMBL9726658 | 0.85 | PDE9A (0.58) | PDE9AKDM4CNPC1PKMRAB9A | |
| SCHEMBL9726564 | 0.83 | PDE9A (0.58) | PDE9AMEN1KMT2AGAAMAPT | |
| SCHEMBL9726447 | 0.80 | PDE9A (0.61) | PDE9AKDM4CNPC1PKMRAB9A | |
| SCHEMBL9726518 | 0.78 | BRD4 (0.51) | PDE9AKDM4CNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16981660 | 0.76 | PDE9A (1.00) | PDE9A | |
| SCHEMBL9726397 | 0.76 | KDM4E (0.45) | PDE9ATSHRLMNAHPGDSMN1; SMN2 | |
| SCHEMBL9726861 | 0.74 | POLB (0.41) | PDE9ATSHRLMNAHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098900-A | Reducing contractions in smooth muscles | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1992-03-24 | — | — | US | disclosed |
| EP-0186817-B1 | 3(2H)PYRIDAZINONE, PROCESS FOR ITS PREPARATION AND ANTI-ALLERGIC AGENT CONTAINING IT | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1989-08-02 | — | — | EP | disclosed |
| EP-0186817-A1 | 3(2H)pyridazinone, process for its preparation and anti-allergic agent containing it | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1986-07-09 | — | — | EP | disclosed |