Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 7/20 | 0.58 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726712 | 0.92 | PDE9A (0.60) | PDE9AKDM4CGAATP53NPC1 | |
| SCHEMBL9726478 | 0.87 | PDE9A (0.48) | PDE9AKDM4CGAATP53NPC1 | |
| SCHEMBL9726400 | 0.85 | PDE9A (0.62) | PDE9AKDM4CGAATP53NPC1 | |
| SCHEMBL9726419 | 0.85 | PDE9A (0.61) | PDE9AKDM4CGAATP53NPC1 | |
| SCHEMBL10601720 | 0.85 | PDE9A (0.61) | PDE9AKDM4CGAATP53NPC1 | |
| SCHEMBL9726473 | 0.84 | PDE9A (0.54) | PDE9A | |
| SCHEMBL9726486 | 0.83 | PDE9A (0.57) | PDE9AGAARAB9AMAPTTSHR | |
| SCHEMBL9726404 | 0.79 | PDE9A (0.49) | PDE9AKDM4CGAATP53NPC1 | |
| SCHEMBL9726447 | 0.77 | PDE9A (0.61) | PDE9AKDM4CGAATP53NPC1 | |
| SCHEMBL9726516 | 0.76 | PDE9A (0.56) | PDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098900-A | Reducing contractions in smooth muscles | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1992-03-24 | — | — | US | disclosed |
| EP-0186817-B1 | 3(2H)PYRIDAZINONE, PROCESS FOR ITS PREPARATION AND ANTI-ALLERGIC AGENT CONTAINING IT | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1989-08-02 | — | — | EP | disclosed |