Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726659 | 0.86 | HMGCR (0.36) | HSD11B1KDM4EHMGCRRAB9ASMN1; SMN2 | |
| SCHEMBL9726666 | 0.86 | HMGCR (0.36) | HSD11B1KDM4EHMGCRRAB9ASMN1; SMN2 | |
| SCHEMBL9726796 | 0.83 | HMGCR (0.32) | HMGCRRAB9ASMN1; SMN2 | |
| SCHEMBL9726424 | 0.83 | HMGCR (0.36) | HMGCRRAB9ASMN1; SMN2ATMNPC1 | |
| SCHEMBL9726403 | 0.83 | TRPM8 (0.42) | HMGCRRAB9ASMN1; SMN2TP53NPC1 | |
| SCHEMBL9726578 | 0.77 | MGAM (0.32) | HSD11B1HMGCRNPC1 | |
| SCHEMBL9726592 | 0.77 | KDM4E (0.39) | HSD11B1KDM4ERAB9ASMN1; SMN2TP53 | |
| SCHEMBL9726603 | 0.76 | HSD17B10 (0.38) | KDM4ERAB9ASMN1; SMN2TP53NPC1 | |
| SCHEMBL9726533 | 0.75 | HMGCR (0.55) | HMGCRTP53ATMUSP2HSD17B10 | |
| SCHEMBL9726819 | 0.73 | MAPT (0.41) | HSD11B1KDM4ERAB9ASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5110940-A | Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase | BRISTOL-MYERS COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| US-5068346-A | Anticholesterol agents | BRISTOL-MYERS COMPANY (US) | 1991-11-26 | — | — | US | disclosed |
| US-4897490-A | DERIVATIVES OF BETA-HYDROXY,OMEGA-DIPHENYL,TETRAZOL-5-YL ALK-OMEGA-ENOIC ACID, ESTER OR LACTONE | BRISTOL-MEYERS COMPANY (US) | 1990-01-30 | — | — | US | disclosed |
| WO-1988006584-A1 | ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS | BRISTOL-MYERS COMPANY (US) | 1988-09-07 | — | — | WO | disclosed |