Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 4/20 | 0.47 |
| ▸ | PDE1A | P54750 | 5/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.42 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.40 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BPTF | Q12830 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726477 | 0.92 | PDE9A (0.48) | PDE9APDE1APDE1BPDE1CAPAF1 | |
| SCHEMBL9726486 | 0.91 | PDE9A (0.57) | PDE9AGRM2 | |
| SCHEMBL9726558 | 0.87 | PDE9A (0.49) | PDE9APDE1APDE1BPDE1CAPAF1 | |
| SCHEMBL9726528 | 0.86 | BRD4 (0.52) | PDE9APDE1APDE1BPDE1CAPAF1 | |
| SCHEMBL9726473 | 0.80 | PDE9A (0.54) | PDE9APDE1APDE1BPDE1CGRM2 | |
| SCHEMBL9726483 | 0.79 | BRD4 (0.41) | PDE9AGRM2BRD9BRD4BPTF | |
| SCHEMBL9726508 | 0.76 | BRD4 (0.52) | PDE9AL3MBTL1BRD9BRD4BPTF | |
| SCHEMBL9726658 | 0.74 | PDE9A (0.58) | PDE9ABRD9SMN1; SMN2 | |
| SCHEMBL9726540 | 0.74 | KDM4E (0.44) | PDE9AAPAF1L3MBTL1SMN1; SMN2 | |
| SCHEMBL9726399 | 0.74 | BRD4 (0.49) | PDE9AGRM2BRD9BRD4BPTF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098900-A | Reducing contractions in smooth muscles | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1992-03-24 | — | — | US | disclosed |
| EP-0186817-B1 | 3(2H)PYRIDAZINONE, PROCESS FOR ITS PREPARATION AND ANTI-ALLERGIC AGENT CONTAINING IT | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1989-08-02 | — | — | EP | disclosed |
| EP-0186817-A1 | 3(2H)pyridazinone, process for its preparation and anti-allergic agent containing it | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1986-07-09 | — | — | EP | disclosed |