Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 6/20 | 0.57 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726499 | 0.91 | PDE9A (0.47) | PDE9AGRM2 | |
| SCHEMBL9726473 | 0.87 | PDE9A (0.54) | PDE9AGRM2 | |
| SCHEMBL9726658 | 0.83 | PDE9A (0.58) | PDE9AALDH1A1TSHRRAB9AGAA | |
| SCHEMBL9726477 | 0.82 | PDE9A (0.48) | PDE9AGRM2GAAMAPT | |
| SCHEMBL9726516 | 0.78 | PDE9A (0.56) | PDE9AGRM2 | |
| SCHEMBL9726558 | 0.77 | PDE9A (0.49) | PDE9AGRM2 | |
| SCHEMBL9726528 | 0.76 | BRD4 (0.52) | PDE9AGRM2ALDH1A1GAAMAPT | |
| SCHEMBL9726712 | 0.74 | PDE9A (0.60) | PDE9AALDH1A1TSHRRAB9AGAA | |
| SCHEMBL16981661 | 0.73 | PDE9A (1.00) | PDE9A | |
| SCHEMBL9726540 | 0.73 | KDM4E (0.44) | PDE9AALDH1A1TSHRGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098900-A | Reducing contractions in smooth muscles | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1992-03-24 | — | — | US | disclosed |
| EP-0186817-B1 | 3(2H)PYRIDAZINONE, PROCESS FOR ITS PREPARATION AND ANTI-ALLERGIC AGENT CONTAINING IT | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1989-08-02 | — | — | EP | disclosed |
| EP-0186817-A1 | 3(2H)pyridazinone, process for its preparation and anti-allergic agent containing it | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1986-07-09 | — | — | EP | disclosed |