Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 9/20 | 0.56 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | PDE6C | P51160 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ASPH | Q12797 | 1/20 | 0.43 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.43 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.43 |
| ▸ | BPTF | Q12830 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726473 | 0.91 | PDE9A (0.54) | PDE9APDE1APDE1BPDE1CPDE5A | |
| SCHEMBL9726564 | 0.86 | PDE9A (0.58) | PDE9APDE1APDE1BPDE1CPDE5A | |
| SCHEMBL9726814 | 0.85 | PDE9A (0.57) | PDE9APDE1APDE1BPDE1CPDE5A | |
| SCHEMBL9726712 | 0.84 | PDE9A (0.60) | PDE9A | |
| SCHEMBL9726540 | 0.82 | KDM4E (0.44) | PDE9AKDM4E | |
| SCHEMBL9726477 | 0.79 | PDE9A (0.48) | PDE9APDE1APDE1BPDE1CGRM2 | |
| SCHEMBL9726486 | 0.78 | PDE9A (0.57) | PDE9AGRM2 | |
| SCHEMBL10601786 | 0.76 | BPTF (0.53) | PDE9APDE1APDE1BPDE1CBPTF | |
| SCHEMBL9726529 | 0.76 | PDE9A (0.45) | PDE9APDE1APDE1BPDE1CBPTF | |
| SCHEMBL9726658 | 0.76 | PDE9A (0.58) | PDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098900-A | Reducing contractions in smooth muscles | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1992-03-24 | — | — | US | disclosed |
| EP-0186817-B1 | 3(2H)PYRIDAZINONE, PROCESS FOR ITS PREPARATION AND ANTI-ALLERGIC AGENT CONTAINING IT | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1989-08-02 | — | — | EP | disclosed |
| EP-0186817-A1 | 3(2H)pyridazinone, process for its preparation and anti-allergic agent containing it | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1986-07-09 | — | — | EP | disclosed |