Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXER1 | Q8TDS5 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 4/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | POLA1 | P09884 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726541 | 1.00 | OXER1 (0.35) | OXER1CNR2CNR1PPARGPPARD | |
| SCHEMBL13071309 | 0.87 | TSHR (0.34) | TSHRPOLBPOLA1 | |
| SCHEMBL9726788 | 0.80 | SLC22A6 (0.50) | CNR2CNR1PPARGPPARDPPARA | |
| SCHEMBL9726786 | 0.80 | SLC22A6 (0.50) | CNR2CNR1PPARGPPARDPPARA | |
| SCHEMBL27257986 | 0.80 | SLC1A1 (0.34) | OXER1CNR2CNR1PPARGPPARD | |
| SCHEMBL28243 | 0.77 | TSHR (0.50) | TSHR | |
| SCHEMBL10300852 | 0.75 | CNR2 (0.40) | CNR2CNR1PPARGPPARDPPARA | |
| SCHEMBL1874566 | 0.75 | CNR2 (0.40) | CNR2CNR1PPARGPPARDPPARA | |
| SCHEMBL9726956 | 0.75 | TSHR (0.34) | TSHR | |
| SCHEMBL9726959 | 0.75 | TSHR (0.34) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5110940-A | Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase | BRISTOL-MYERS COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| US-5068346-A | Anticholesterol agents | BRISTOL-MYERS COMPANY (US) | 1991-11-26 | — | — | US | disclosed |
| US-4898950-A | Preparation of antihypercholesterolemic tetrazole compounds | BRISTOL-MYERS COMPANY (US) | 1990-02-06 | — | — | US | disclosed |
| US-4897490-A | DERIVATIVES OF BETA-HYDROXY,OMEGA-DIPHENYL,TETRAZOL-5-YL ALK-OMEGA-ENOIC ACID, ESTER OR LACTONE | BRISTOL-MEYERS COMPANY (US) | 1990-01-30 | — | — | US | disclosed |
| CN-1036013-A | The tetrazole compound that antihypercholesterolemic is too high and the preparation of intermediate thereof | BRISTOL MYERS CO (US) | 1989-10-04 | — | — | CN | disclosed |
| US-4824959-A | Intermediates for antihypercholesterolemic tetrazole compounds | BRISTOL-MYERS COMPANY (US) | 1989-04-25 | — | — | US | disclosed |
| CN-88100911-A | Antihypercholesterolemic tetrazolium compounds | — | 1988-09-28 | — | — | CN | disclosed |
| WO-1988006584-A1 | ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS | BRISTOL-MYERS COMPANY (US) | 1988-09-07 | — | — | WO | disclosed |