Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9726959 | 1.00 | TSHR (0.34) | TSHRMEN1KMT2A | |
| SCHEMBL5497077 | 0.75 | TSHR (0.39) | TSHRMEN1KMT2A | |
| SCHEMBL14523084 | 0.75 | TSHR (0.39) | TSHRMEN1KMT2A | |
| SCHEMBL9726544 | 0.75 | OXER1 (0.35) | TSHR | |
| SCHEMBL9726541 | 0.75 | OXER1 (0.35) | TSHR | |
| SCHEMBL1874566 | 0.73 | CNR2 (0.40) | TSHR | |
| SCHEMBL10300852 | 0.73 | CNR2 (0.40) | TSHR | |
| SCHEMBL1874564 | 0.73 | CNR2 (0.40) | TSHR | |
| SCHEMBL1660808 | 0.73 | AKT1 (0.40) | TSHRKMT2A | |
| SCHEMBL1040066 | 0.73 | AKT1 (0.40) | TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5110940-A | Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase | BRISTOL-MYERS COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| US-5068346-A | Anticholesterol agents | BRISTOL-MYERS COMPANY (US) | 1991-11-26 | — | — | US | disclosed |
| US-4898950-A | Preparation of antihypercholesterolemic tetrazole compounds | BRISTOL-MYERS COMPANY (US) | 1990-02-06 | — | — | US | disclosed |
| US-4897490-A | DERIVATIVES OF BETA-HYDROXY,OMEGA-DIPHENYL,TETRAZOL-5-YL ALK-OMEGA-ENOIC ACID, ESTER OR LACTONE | BRISTOL-MEYERS COMPANY (US) | 1990-01-30 | — | — | US | disclosed |
| US-4824959-A | Intermediates for antihypercholesterolemic tetrazole compounds | BRISTOL-MYERS COMPANY (US) | 1989-04-25 | — | — | US | disclosed |
| WO-1988006584-A1 | ANTIHYPERCHOLESTEROLEMIC TETRAZOLE COMPOUNDS | BRISTOL-MYERS COMPANY (US) | 1988-09-07 | — | — | WO | disclosed |