Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 9/20 | 0.40 |
| ▸ | CNR1 | P21554 | 7/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1874566 | 1.00 | CNR2 (0.40) | CNR2CNR1PPARGPPARDPPARA | |
| SCHEMBL10300852 | 1.00 | CNR2 (0.40) | CNR2CNR1PPARGPPARDPPARA | |
| SCHEMBL7187330 | 0.88 | TSHR (0.38) | PPARGPPARDPPARAALDH1A1TSHR | |
| SCHEMBL7187331 | 0.88 | TSHR (0.38) | PPARGPPARDPPARAALDH1A1TSHR | |
| SCHEMBL6128466 | 0.83 | ALDH1A1 (0.35) | ALDH1A1TSHR | |
| SCHEMBL8517154 | 0.83 | ALDH1A1 (0.35) | ALDH1A1TSHR | |
| SCHEMBL1883670 | 0.81 | GPR84 (0.43) | CNR2CNR1PPARGPPARDPPARA | |
| SCHEMBL10300841 | 0.81 | CNR2 (0.39) | CNR2CNR1PPARGPPARDPPARA | |
| SCHEMBL13156318 | 0.81 | GPR84 (0.43) | CNR2CNR1PPARGPPARDPPARA | |
| SCHEMBL1883672 | 0.81 | GPR84 (0.43) | CNR2CNR1PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029593-B2 | Method for manufacturing spilanthol and intermediate manufacturing product therefor | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2015-05-12 | — | — | US | disclosed |
| EP-2455363-B1 | METHOD FOR MANUFACTURING SPILANTHOL AND INTERMEDIATE MANUFACTURING PRODUCT THEREFOR | TAKASAGO PERFUMERY CO LTD (JP) | 2014-10-01 | — | — | EP | disclosed |
| US-8217192-B2 | Production method of (2E,6Z,8E)-N-isobutyl-2,6,8-decatrienamide (spilanthol), and food or drink, fragrance or cosmetic, or pharmaceutical comprising the same | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2012-07-10 | — | — | US | disclosed |
| EP-2455363-A1 | METHOD FOR MANUFACTURING SPILANTHOL AND INTERMEDIATE MANUFACTURING PRODUCT THEREFOR | Takasago International Corporation (JP) | 2012-05-23 | — | — | EP | disclosed |
| US-20120116116-A1 | METHOD FOR MANUFACTURING SPILANTHOL AND INTERMEDIATE MANUFACTURING PRODUCT THEREFOR | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2012-05-10 | — | — | US | disclosed |
| US-20110105773-A1 | PRODUCTION METHOD OF (2E,6Z,8E)-N-ISOBUTYL-2,6,8-DECATRIENAMIDE (SPILANTHOL), AND FOOD OR DRINK, FRAGRANCE OR COSMETIC, OR PHARMACEUTICAL COMPRISING THE SAME | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2011-05-05 | — | — | US | disclosed |
| EP-2236489-A1 | METHOD FOR PRODUCTION OF (2E,6Z,8E)-N-ISOBUTYL-2,6,8-DECATRIENAMIDE (SPILANTHOL), AND FOODS, BEVERAGES, COSMETICS AND PHARMACEUTICAL PREPARATIONS EACH COMPRISING THE COMPOUND | Takasago International Corporation (JP) | 2010-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105773-A1 | PRODUCTION METHOD OF (2E,6Z,8E)-N-ISOBUTYL-2,6,8-DECATRIENAMIDE (SPILANTHOL), AND FOOD OR DRINK, FRAGRANCE OR COSMETIC, OR PHARMACEUTICAL COMPRISING THE SAME | NISCH, FAAH2, ADH5 | CNR2 7/4885CNR1 43/4885PPARG 351/4885 |
| US-20120116116-A1 | METHOD FOR MANUFACTURING SPILANTHOL AND INTERMEDIATE MANUFACTURING PRODUCT THEREFOR | CYP4A11, CYP4F8, CYP51A1 | CNR2 522/4885CNR1 363/4885PPARG 374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.