Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.54 |
| ▸ | CCR3 | P51677 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727190 | 0.91 | DRD4 (0.62) | DRD4SIGMAR1MCHR1CCR3MAOB | |
| SCHEMBL9727435 | 0.88 | DRD4 (0.57) | DRD4SIGMAR1DRD3SLC6A12MCHR1 | |
| SCHEMBL9727095 | 0.87 | DRD4 (0.72) | DRD4SIGMAR1MCHR1CCR3MAOB | |
| SCHEMBL9727082 | 0.80 | DRD4 (0.64) | DRD4SIGMAR1DRD3MCHR1CCR3 | |
| SCHEMBL9852087 | 0.80 | DRD4 (0.61) | DRD4SIGMAR1MCHR1CCR3KCNH2 | |
| SCHEMBL9852082 | 0.80 | DRD4 (0.73) | DRD4SIGMAR1MCHR1CCR3KCNH2 | |
| SCHEMBL9727235 | 0.80 | DRD4 (0.58) | DRD4SIGMAR1MCHR1CCR3KCNH2 | |
| Iodide SCHEMBL9852255 | 0.78 | DRD4 (0.60) | DRD4SIGMAR1MCHR1CCR3KCNH2 | |
| SCHEMBL9852245 | 0.78 | DRD4 (0.55) | DRD4SIGMAR1MCHR1MAOB | |
| SCHEMBL9727149 | 0.77 | DRD4 (0.58) | DRD4SIGMAR1MCHR1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098915-A | Antiarrhythmia agents | G. D. SEARLE & CO. (US) | 1992-03-24 | — | — | US | claimed |
| EP-0416581-A1 | Substituted N-benzylpiperidine amides | G.D. Searle & Co. (US) | 1991-03-13 | — | — | EP | claimed |