Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.64 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 2/20 | 0.57 |
| ▸ | CCR3 | P51677 | 2/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727182 | 0.91 | DRD4 (0.64) | DRD4MCHR1KCNH2KDM4EALDH1A1 | |
| SCHEMBL9727416 | 0.88 | DRD4 (0.60) | DRD4MCHR1KCNH2KDM4EALDH1A1 | |
| SCHEMBL9727091 | 0.85 | DRD4 (0.70) | DRD4MCHR1KCNH2KDM4EALDH1A1 | |
| SCHEMBL9852064 | 0.82 | MCHR1 (0.66) | DRD4MCHR1KCNH2KDM4EALDH1A1 | |
| SCHEMBL6837609 | 0.81 | ADORA2A (0.69) | KDM4EALDH1A1HPGDHSD17B10CHRNA7 | |
| SCHEMBL6839051 | 0.81 | ADORA2A (0.72) | KDM4EALDH1A1HPGDHSD17B10CHRNA7 | |
| SCHEMBL9727088 | 0.80 | DRD4 (0.62) | DRD4MCHR1KCNH2CCR3SIGMAR1 | |
| SCHEMBL9727231 | 0.80 | MCHR1 (0.64) | DRD4MCHR1KCNH2KDM4EALDH1A1 | |
| SCHEMBL9852062 | 0.78 | DRD4 (0.71) | DRD4MCHR1KCNH2KDM4EALDH1A1 | |
| SCHEMBL9852060 | 0.78 | ACHE (0.60) | DRD4MCHR1KCNH2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098915-A | Antiarrhythmia agents | G. D. SEARLE & CO. (US) | 1992-03-24 | — | — | US | claimed |
| EP-0416581-A1 | Substituted N-benzylpiperidine amides | G.D. Searle & Co. (US) | 1991-03-13 | — | — | EP | claimed |