Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.72 |
| ▸ | DRD4 | P21917 | 2/20 | 0.65 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CCR3 | P51677 | 1/20 | 0.59 |
| ▸ | LTA4H | P09960 | 2/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9871216 | 0.87 | LTA4H (0.60) | SIGMAR1HRH3LTA4HKCNH2ALDH1A1 | |
| SCHEMBL16572276 | 0.85 | BCHE (0.61) | SIGMAR1DRD4MCHR1LTA4HKCNH2 | |
| SCHEMBL12184810 | 0.85 | SIGMAR1 (0.67) | SIGMAR1DRD4MCHR1KMT2ALTA4H | |
| SCHEMBL9852171 | 0.84 | SIGMAR1 (0.65) | SIGMAR1DRD4MCHR1HRH3MEN1 | |
| SCHEMBL9872559 | 0.84 | DRD4 (0.78) | SIGMAR1DRD4MCHR1MEN1KMT2A | |
| SCHEMBL5862230 | 0.84 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL9852165 | 0.84 | SIGMAR1 (0.65) | SIGMAR1DRD4MCHR1HRH3MEN1 | |
| SCHEMBL7475783 | 0.84 | SIGMAR1 (0.65) | SIGMAR1DRD4MCHR1HRH3MEN1 | |
| SCHEMBL4592089 | 0.83 | SIGMAR1 (0.68) | SIGMAR1DRD4MCHR1KMT2ALTA4H | |
| SCHEMBL3164487 | 0.83 | SIGMAR1 (0.74) | SIGMAR1DRD4MCHR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5098915-A | Antiarrhythmia agents | G. D. SEARLE & CO. (US) | 1992-03-24 | — | — | US | disclosed |
| US-5053413-A | Antiarrhythmia agent | G. D. SEARLE & CO. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0416581-A1 | Substituted N-benzylpiperidine amides | G.D. Searle & Co. (US) | 1991-03-13 | — | — | EP | disclosed |