Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | DRD5 | P21918 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4215401 | 0.97 | CHRM2 (0.55) | CHRM2CHRM1CHRM3SIGMAR1MTNR1A | |
| SCHEMBL11393302 | 0.96 | SIGMAR1 (0.54) | CHRM2CHRM1CHRM3SIGMAR1MTNR1A | |
| SCHEMBL8677765 | 0.96 | SIGMAR1 (0.54) | CHRM2CHRM1CHRM3SIGMAR1MTNR1A | |
| Hydrochloric Acid SCHEMBL7933015 | 0.94 | SIGMAR1 (0.53) | CHRM2CHRM1CHRM3SIGMAR1MTNR1A | |
| Hydrochloric Acid SCHEMBL7935858 | 0.94 | SIGMAR1 (0.53) | CHRM2CHRM1CHRM3SIGMAR1MTNR1A | |
| SCHEMBL9239027 | 0.90 | DRD2 (0.54) | CHRM2CHRM1CHRM3SIGMAR1DRD2 | |
| Hydrochloric Acid SCHEMBL9243515 | 0.89 | DRD2 (0.52) | CHRM2CHRM1CHRM3SIGMAR1DRD2 | |
| Hydrochloric Acid SCHEMBL9242362 | 0.89 | DRD2 (0.52) | CHRM2CHRM1CHRM3SIGMAR1DRD2 | |
| SCHEMBL8674841 | 0.89 | CHRM2 (0.56) | CHRM2CHRM1CHRM3SIGMAR1MTNR1A | |
| Hydrochloric Acid SCHEMBL7932854 | 0.87 | CHRM2 (0.55) | CHRM2CHRM1CHRM3SIGMAR1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164385-A | AZETIDINE DERIVATIVES AND HYPOTENSIVE COMPOSITIONS THEREOF | JOHN WYETH & BROTHER, LTD. (GB) | 1992-11-17 | — | — | US | claimed |
| US-5164385-A | AZETIDINE DERIVATIVES AND HYPOTENSIVE COMPOSITIONS THEREOF | JOHN WYETH & BROTHER, LTD. (GB) | 1992-11-17 | — | — | US | disclosed |