Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 9/20 | 0.46 |
| ▸ | HTR2C | P28335 | 8/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9865925 | 0.95 | HTR6 (0.45) | HTR6HTR2CHTR1ASLC6A2SLC6A4 | |
| SCHEMBL9727510 | 0.94 | HTR2C (0.51) | HTR6HTR2CHTR1ASLC6A2SLC6A4 | |
| SCHEMBL9732296 | 0.84 | HTR6 (0.42) | HTR6HTR2C | |
| SCHEMBL9727253 | 0.84 | PTGS2 (0.46) | — | |
| SCHEMBL23045663 | 0.82 | HSD11B1 (0.44) | HTR6HTR2C | |
| SCHEMBL6606000 | 0.78 | HTR2C (0.56) | HTR6HTR2CHTR1ASLC6A2SLC6A4 | |
| SCHEMBL4623351 | 0.78 | HTR2C (0.51) | HTR6HTR2CHTR1ASLC6A2SLC6A4 | |
| SCHEMBL29764435 | 0.78 | HTR2C (0.51) | HTR6HTR2CHTR1ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL4891683 | 0.76 | HTR2C (0.57) | HTR6HTR2CHTR1ASLC6A2SLC6A4 | |
| SCHEMBL7819186 | 0.74 | HTR2C (0.51) | HTR6HTR2CHTR1ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164514-A | Antispasmodics | ROUSSEL UCLAF (FR) | 1992-11-17 | — | — | US | disclosed |
| US-5081130-A | Antispasmodic agents | ROUSSEL UCLAF (FR) | 1992-01-14 | — | — | US | disclosed |
| US-5041436-A | 1-arylsulphonyl-2-piperidinone derivatives, process and intermediates for the preparation thereof, their application as antispasmodics and compositions containing them | ROUSSEL UCLAF (FR) | 1991-08-20 | — | — | US | disclosed |
| US-5037822-A | Antispasmodic agent | ROUSSEL-UCLAF (FR) | 1991-08-06 | — | — | US | disclosed |
| US-4990531-A | Antispasmodic agents | ROUSSEL UCLAF (FR) | 1991-02-05 | — | — | US | disclosed |