SCHEMBL9727358

SCHEMBL9727358

CC1(C)c2cc(OCc3ccccc3)ccc2OC1C=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 11/20 0.45
MAOA P21397 7/20 0.45
KCNE1 P15382 3/20 0.43
KCNQ1 P51787 3/20 0.43
ACHE P22303 1/20 0.43
CA2 P00918 2/20 0.42
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA9 Q16790 1/20 0.42
NPC1 O15118 1/20 0.42
ALDH1A1 P00352 1/20 0.42
HPGD P15428 1/20 0.42
NFKB1 P19838 1/20 0.42
GRM5 P41594 1/20 0.42
RAB9A P51151 1/20 0.42
NFKB2 Q00653 1/20 0.42
RELA Q04206 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
ALOX5 P09917 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9727671 0.79 MAOB (0.46) MAOBMAOAKCNE1KCNQ1ACHE
SCHEMBL27707850 0.71 MAOB (0.50) MAOBMAOAKCNE1KCNQ1CA2
SCHEMBL11516737 0.70 HRH3 (0.44) MAOBMAOAACHENPC1RAB9A
SCHEMBL28877586 0.69 MAOB (0.54) MAOBMAOAKCNE1KCNQ1ACHE
SCHEMBL632288 0.69 MAOB (0.48) MAOBMAOAKCNE1KCNQ1ACHE
SCHEMBL21198815 0.69 MAOB (0.59) MAOBMAOACA2NPC1ALDH1A1
SCHEMBL21198816 0.69 MAOB (0.59) MAOBMAOACA2NPC1ALDH1A1
SCHEMBL12471199 0.69 HRH3 (0.51) MAOBMAOAALOX5
SCHEMBL24239411 0.68 MAOB (0.51) MAOBMAOACA2CA12CA1
SCHEMBL10509355 0.68 ITGB3 (0.52) MAOBMAOACA2NPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5091533-A Treating allergies, cardiovascular disorders, inflammation MERCK FROSST CANADA, INC. (CA) 1992-02-25 US disclosed
EP-0447189-A1 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors MERCK FROSST CANADA INC. (CA) 1991-09-18 EP disclosed