Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727358 | 0.79 | MAOB (0.45) | MAOBMAOAKCNE1KCNQ1ALOX5 | |
| SCHEMBL9727622 | 0.75 | GAA (0.50) | PTGS1PTGS2 | |
| SCHEMBL568147 | 0.68 | MAOB (0.60) | MAOBMAOAALOX5HTR6 | |
| SCHEMBL568146 | 0.68 | MAOB (0.60) | MAOBMAOAALOX5HTR6 | |
| SCHEMBL21198165 | 0.68 | MAOB (0.60) | MAOBMAOAALOX5HTR6 | |
| SCHEMBL566991 | 0.68 | MAOB (0.60) | MAOBMAOAALOX5HTR6 | |
| SCHEMBL566990 | 0.68 | MAOB (0.60) | MAOBMAOAALOX5HTR6 | |
| SCHEMBL6936669 | 0.68 | CA2 (0.54) | MAOBMAOAALOX5HIF1A | |
| SCHEMBL11515721 | 0.68 | CREBBP (0.53) | MAOBMAOAALOX5PDK2HTR2B | |
| SCHEMBL12502194 | 0.68 | MAOB (0.68) | MAOBMAOAHTR2BTMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |