SCHEMBL11516737

SCHEMBL11516737

CC1N(C=O)c2ccc(OCc3ccccc3)cc2C1(C)C

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 5/20 0.44
MAOA P21397 5/20 0.42
MAOB P27338 5/20 0.42
MEN1 O00255 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
KMT2A Q03164 1/20 0.41
FSHR P23945 1/20 0.41
CREBBP Q92793 1/20 0.41
ALOX5 P09917 1/20 0.40
SRD5A1 P18405 1/20 0.40
ACHE P22303 2/20 0.40
BCHE P06276 1/20 0.40
TP53 P04637 1/20 0.40
KDM1A O60341 1/20 0.40
CYP2D6 P10635 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11514825 0.81 ACHE (0.38) MEN1NPC1RAB9AKMT2AACHE
SCHEMBL11515180 0.79 ACHE (0.41) MEN1KMT2AACHEBCHE
SCHEMBL11515997 0.72 PARK7 (0.41) ACHEBCHE
SCHEMBL11515580 0.71 KMT2A (0.37) MEN1KMT2ASRD5A1ACHEBCHE
SCHEMBL28250868 0.70 POLB (0.48) HRH3MAOAMAOBMEN1NPC1
SCHEMBL9727358 0.70 MAOB (0.45) MAOAMAOBNPC1RAB9AALOX5
SCHEMBL6234715 0.70 TP53 (0.43) HRH3MAOAMAOBMEN1NPC1
SCHEMBL11515721 0.69 CREBBP (0.53) HRH3MAOAMAOBMEN1NPC1
SCHEMBL17771778 0.69 HRH3 (0.52) HRH3MAOAMAOBMEN1NPC1
SCHEMBL9750432 0.68 HRH3 (0.48) HRH3MAOAMAOBMEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4145537-A BENZOTHIAZOLIUM DYES BAYER AKTIENGESELLSCHAFT (DE) 1979-03-20 US disclosed