Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREB1 | P16220 | 3/20 | 0.70 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL971180 | 0.94 | CREB1 (0.66) | CREB1ABCG2ABCB1KDM4ECYP3A4 | |
| SCHEMBL970574 | 0.92 | CREB1 (0.64) | CREB1ABCG2ABCB1KDM4ECYP3A4 | |
| SCHEMBL972837 | 0.91 | CREB1 (0.80) | CREB1ABCG2ABCB1KDM4ECYP3A4 | |
| SCHEMBL970007 | 0.90 | CREB1 (0.65) | CREB1ABCG2ABCB1KDM4ECYP3A4 | |
| SCHEMBL29008532 | 0.90 | CREB1 (0.86) | CREB1ABCG2ABCB1KDM4ECYP3A4 | |
| SCHEMBL974333 | 0.89 | ABCB1 (0.68) | CREB1ABCG2ABCB1KDM4ECYP3A4 | |
| SCHEMBL970573 | 0.89 | CREB1 (0.63) | CREB1ABCG2ABCB1KDM4ECYP3A4 | |
| SCHEMBL16499864 | 0.89 | KDM4E (0.69) | CREB1KDM4ECYP3A4MAPTHSD17B10 | |
| SCHEMBL970006 | 0.87 | CREB1 (0.61) | CREB1ABCG2ABCB1KDM4ECYP3A4 | |
| SCHEMBL22966699 | 0.85 | CREB1 (0.82) | CREB1ABCG2ABCB1KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111303106-B | Preparation method of 5, 6-diacetoxy-7-hydroxy flavone | 武汉轻工大学 | 2023-06-02 | — | — | CN | claimed |
| CN-111303106-A | Preparation method of 5, 6-diacetoxy-7-hydroxyflavone | 武汉轻工大学 | 2020-06-19 | — | — | CN | claimed |
| CN-111100103-A | Method for synthesizing oroxylin | 北京恩成康泰生物科技有限公司 | 2020-05-05 | — | — | CN | claimed |
| CN-111303106-B | Preparation method of 5, 6-diacetoxy-7-hydroxy flavone | 武汉轻工大学 | 2023-06-02 | — | — | CN | disclosed |
| CN-111303106-B | Preparation method of 5, 6-diacetoxy-7-hydroxy flavone | 武汉轻工大学 | 2023-06-02 | — | — | CN | disclosed |
| WO-2022255765-A1 | NOVEL FLUORINE-SUBSTITUTED FLAVONOID DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ALLERGIC DISEASES, COMPRISING SAME | 주식회사 에즈큐리스 | 2022-12-08 | — | — | WO | disclosed |
| CN-111303106-A | Preparation method of 5, 6-diacetoxy-7-hydroxyflavone | 武汉轻工大学 | 2020-06-19 | — | — | CN | disclosed |
| CN-111303106-A | Preparation method of 5, 6-diacetoxy-7-hydroxyflavone | 武汉轻工大学 | 2020-06-19 | — | — | CN | disclosed |
| CN-111100103-A | Method for synthesizing oroxylin | 北京恩成康泰生物科技有限公司 | 2020-05-05 | — | — | CN | disclosed |
| US-7875650-B2 | Baicalein analogs; enhances bioavailability of active compounds, especially orally administered compounds, by inhibition of P-glycoprotein 170 (P-gp 170) and/or CYP450 enzyme; 6-Acetoxy-5,7-dihydroxyflavone | YALE UNIVERSITY (US) | 2011-01-25 | — | — | US | disclosed |
| US-20070161605-A1 | Compounds and methods to increase anti-p-glycoprotein activity of baicalein by alkylation on the a ring | YALE UNIVERSITY (US) | 2007-07-12 | — | — | US | disclosed |
| WO-2005075449-A1 | COMPOUNDS AND METHODS TO INCREASE ANTI-P-GLYCOPROTEIN ACTIVITY OF BAICALEIN BY ALKYLATION ON THE A RING | YALE UNIVERSITY (US) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161605-A1 | Compounds and methods to increase anti-p-glycoprotein activity of baicalein by alkylation on the a ring | ABCB1, ABCB11, ABCG2 | CREB1 2524/4885ABCG2 3/4885ABCB1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.