Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.61 |
| ▸ | NPC1 | O15118 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.53 |
| ▸ | TUBB | P07437 | 1/20 | 0.53 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.53 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.53 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.53 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.53 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28217436 | 0.86 | NPC1 (0.58) | MAPTSMN1; SMN2NPC1ALDH1A1RAB9A | |
| SCHEMBL28209634 | 0.83 | NPC1 (0.64) | MAPTSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL716903 | 0.83 | RAB9A (0.74) | MAPTSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL11823964 | 0.82 | MAPT (0.73) | MAPTSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL9740353 | 0.82 | KDM4E (0.58) | MAPTSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL9486652 | 0.82 | HTT (0.64) | MAPTSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL9741101 | 0.80 | KDM4E (0.56) | MAPTSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| Acetic Acid SCHEMBL5511893 | 0.79 | MAPT (0.68) | MAPTSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL1287500 | 0.77 | SLC22A12 (0.86) | MAPTSMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL10460563 | 0.75 | KDM4E (0.47) | MAPTSMN1; SMN2KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |