Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9799573 | 0.92 | TP53 (0.46) | TP53GAAL3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL9354590 | 0.88 | TP53 (0.42) | TP53GAATSHRMAPK1RECQL | |
| SCHEMBL9658919 | 0.87 | GAA (0.44) | TP53GAAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL9350861 | 0.83 | MEN1 (0.46) | TP53GAAALDH1A1L3MBTL1LMNA | |
| SCHEMBL9727635 | 0.80 | GAA (0.46) | TP53GAAMEN1KMT2AAKR1C3 | |
| SCHEMBL9727624 | 0.79 | GAA (0.48) | TP53GAAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL9621784 | 0.78 | TSHR (0.61) | TP53GAAALDH1A1TSHRMAPK1 | |
| SCHEMBL9727673 | 0.78 | KMT2A (0.43) | TP53GAANLRP3TSHRMAPK1 | |
| SCHEMBL9350725 | 0.75 | GAA (0.43) | TP53GAAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7383735 | 0.74 | MMP2 (0.64) | TP53GAAALDH1A1RECQLL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164514-A | Antispasmodics | ROUSSEL UCLAF (FR) | 1992-11-17 | — | — | US | disclosed |
| US-5081130-A | Antispasmodic agents | ROUSSEL UCLAF (FR) | 1992-01-14 | — | — | US | disclosed |
| US-4990531-A | Antispasmodic agents | ROUSSEL UCLAF (FR) | 1991-02-05 | — | — | US | disclosed |
| EP-0335758-A2 | Derivatives of 1-arylsulfonyl-2-pyrolidinone, process for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1989-10-04 | — | — | EP | disclosed |