Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9727754 | 0.78 | GABRA1 (0.35) | PTPN1SRD5A1 | |
| SCHEMBL9727666 | 0.75 | GABRA1 (0.38) | PTPN1SRD5A1 | |
| SCHEMBL9727746 | 0.74 | GABRA1 (0.36) | PTPN1SRD5A1 | |
| SCHEMBL3267701 | 0.64 | MAPK1 (0.47) | PTPN1KDM4EMAPK1HSD17B10L3MBTL1 | |
| SCHEMBL11240911 | 0.63 | KDM4E (0.51) | PTPN1KDM4EMAPK1HSD17B10 | |
| SCHEMBL24302315 | 0.62 | MAPT (0.41) | PTPN1KDM4EMAPK1HSD17B10SRD5A1 | |
| SCHEMBL8417673 | 0.62 | PTPN1 (0.59) | PTPN1KDM4EHSD17B10L3MBTL1 | |
| SCHEMBL8418573 | 0.62 | FDFT1 (0.52) | PTPN1MAPK1 | |
| SCHEMBL1975607 | 0.61 | GABRA1 (0.53) | PTPN1KDM4ESRD5A1 | |
| SCHEMBL8417975 | 0.61 | HTT (0.48) | PTPN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091533-A | Treating allergies, cardiovascular disorders, inflammation | MERCK FROSST CANADA, INC. (CA) | 1992-02-25 | — | — | US | disclosed |
| EP-0447189-A1 | 5-Hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors | MERCK FROSST CANADA INC. (CA) | 1991-09-18 | — | — | EP | disclosed |