Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | GLA | P06280 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20604035 | 0.86 | KDM4E (0.58) | TDP1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL29706045 | 0.86 | KDM4E (0.58) | TDP1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL27450149 | 0.82 | ALDH1A1 (0.60) | TDP1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL9936015 | 0.81 | ALDH1A1 (0.55) | TDP1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL29562242 | 0.81 | ALDH1A1 (0.55) | KDM4EALDH1A1KMT2AMEN1GLA | |
| SCHEMBL29706153 | 0.81 | TDP1 (0.70) | TDP1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL1629133 | 0.81 | TDP1 (0.70) | TDP1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL31574332 | 0.81 | ALDH1A1 (0.55) | TDP1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL9936012 | 0.81 | KMT2A (0.55) | TDP1KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL28201815 | 0.81 | ALDH1A1 (0.55) | KDM4EALDH1A1KMT2AMEN1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151518-A | N-arylation of isatins | ABBOTT LABORATORIES (US) | 1992-09-29 | — | — | US | disclosed |