SCHEMBL9936015

SCHEMBL9936015

OCc1cccc2nc3ccccc3cc12

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.55
GLA P06280 4/20 0.55
POLB P06746 4/20 0.55
KDM4E B2RXH2 4/20 0.55
KMT2A Q03164 4/20 0.55
HPGD P15428 3/20 0.55
RAB9A P51151 3/20 0.55
LMNA P02545 2/20 0.55
GAA P10253 2/20 0.55
NPC1 O15118 1/20 0.55
PTBP1 P26599 1/20 0.55
RCE1 Q9Y256 1/20 0.55
TOP2A P11388 2/20 0.50
TOP2B Q02880 2/20 0.50
ACHE P22303 2/20 0.50
MAPT P10636 1/20 0.50
RAD52 P43351 3/20 0.43
ESR1 P03372 2/20 0.43
ESR2 Q92731 2/20 0.43
MITF O75030 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31574332 1.00 ALDH1A1 (0.55) ALDH1A1GLAPOLBKDM4EKMT2A
SCHEMBL30376957 0.86 ALDH1A1 (0.51) ALDH1A1GLAPOLBKDM4EKMT2A
SCHEMBL1484136 0.86 ALDH1A1 (0.51) ALDH1A1GLAPOLBKDM4EKMT2A
SCHEMBL4281890 0.85 KMT2A (0.58) ALDH1A1GLAPOLBKDM4EKMT2A
SCHEMBL29631756 0.85 KMT2A (0.58) ALDH1A1GLAPOLBKDM4EKMT2A
SCHEMBL23421423 0.85 KMT2A (0.58) ALDH1A1GLAPOLBKDM4EKMT2A
SCHEMBL7145834 0.81 ALDH1A1 (0.59) ALDH1A1GLAPOLBKDM4EKMT2A
SCHEMBL9936012 0.81 KMT2A (0.55) ALDH1A1GLAPOLBKDM4EKMT2A
SCHEMBL22497413 0.81 ALDH1A1 (0.55) ALDH1A1GLAPOLBKDM4EKMT2A
SCHEMBL291405 0.81 KMT2A (0.55) ALDH1A1GLAPOLBKDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118021990-A Prodrug composition and method for activating radiation catalytic drug 北京师范大学 2024-05-14 CN disclosed
US-10913936-B2 Phenazine degrading agents and related compositions, methods and systems for interfering with viability of bacteria CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2021-02-09 US disclosed
US-20210032603-A1 PHENAZINE DEGRADING AGENTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS FOR INTERFERING WITH VIABILITY OF BACTERIA CALIFORNIA INSTITUTE OF TECHNOLOGY 2021-02-04 US disclosed
US-20170275597-A1 PHENAZINE DEGRADING AGENTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS FOR INTERFERING WITH VIABILITY OF BACTERIA CALIFORNIA INSTITUTE OF TECHNOLOGY 2017-09-28 US disclosed
WO-2017165578-A1 Phenazine Degrading Agents and related Compositions, Methods and Systems for Interfering with Viability of Bacteria CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2017-09-28 WO disclosed
CN-104844736-B Fluoridize hydrogen-abstraction Polymeric photoinitiators, preparation method and application thereof SHANGHAI JIAO TONG UNIVERSITY (CN) 2016-03-30 CN disclosed
US-20150266839-A1 CYCLIC AMIDE DERIVATIVE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2015-09-24 US disclosed
CN-104844736-A Fluorated hydrogen abstracting type macromolecular photoinitiator, and preparation method and application thereof UNIV SHANGHAI JIAOTONG 2015-08-19 CN disclosed
US-20150225392-A1 CYCLIC AMIDE DERIVATIVE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2015-08-13 US disclosed
US-9072758-B2 Cyclic amide derivative MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2015-07-07 US disclosed
US-20130217690-A1 NOVEL 3-HYDROXYISOTHIAZOLE 1-OXIDE DERIVATIVES MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2013-08-22 US disclosed
US-20130210721-A1 NOVEL 3-HYDROXYISOTHIAZOLE 1-OXIDE DERIVATIVES MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2013-08-15 US disclosed
US-20130203739-A1 CYCLIC AMIDE DERIVATIVE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2013-08-08 US disclosed
US-8476287-B2 3-hydroxy-5-arylisothiazole derivative MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2013-07-02 US disclosed
US-8455500-B2 3-hydroxy-5-arylisoxazole derivative MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2013-06-04 US disclosed
US-20120277150-A1 NOVEL 3-HYDROXYISOTHIAZOLE 1-OXIDE DERIVATIVE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2012-11-01 US disclosed
EP-2518060-A1 NOVEL 3-HYDROXY-5-ARYLISOTHIAZOLE DERIVATIVE Mochida Pharmaceutical Co., Ltd. (JP) 2012-10-31 EP disclosed
EP-2495238-A1 NOVEL 3-HYDROXY-5-ARYLISOXAZOLE DERIVATIVE Mochida Pharmaceutical Co., Ltd. (JP) 2012-09-05 EP disclosed
US-20120220772-A1 NOVEL 3-HYDROXY-5-ARYLISOXAZOLE DERIVATIVE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2012-08-30 US disclosed
US-20120157459-A1 NOVEL 3-HYDROXY-5-ARYLISOTHIAZOLE DERIVATIVE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2012-06-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150266839-A1 CYCLIC AMIDE DERIVATIVE GPR119, NR0B1, NR4A1 ALDH1A1 3399/4885GLA 3324/4885POLB 4232/4885
US-20130210721-A1 NOVEL 3-HYDROXYISOTHIAZOLE 1-OXIDE DERIVATIVES GPR119, GPR27, GPR65 ALDH1A1 2526/4885GLA 3304/4885POLB 4708/4885
US-20130217690-A1 NOVEL 3-HYDROXYISOTHIAZOLE 1-OXIDE DERIVATIVES GPR119, GPR27, GPR65 ALDH1A1 2526/4885GLA 3304/4885POLB 4708/4885
US-20170275597-A1 PHENAZINE DEGRADING AGENTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS FOR INTERFERING WITH VIABILITY OF BACTERIA PGLS, CLPP, BLVRB ALDH1A1 1284/4885GLA 317/4885POLB 121/4885
US-20150225392-A1 CYCLIC AMIDE DERIVATIVE GPR119, NR0B1, NR2C2 ALDH1A1 3218/4885GLA 3502/4885POLB 4263/4885
US-20120157459-A1 NOVEL 3-HYDROXY-5-ARYLISOTHIAZOLE DERIVATIVE GPR119, GPR27, NR0B1 ALDH1A1 2875/4885GLA 3576/4885POLB 4698/4885
US-10913936-B2 Phenazine degrading agents and related compositions, methods and systems for interfering with viability of bacteria PGLS, CLPP, BLVRB ALDH1A1 1284/4885GLA 317/4885POLB 121/4885
US-20210032603-A1 PHENAZINE DEGRADING AGENTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS FOR INTERFERING WITH VIABILITY OF BACTERIA PGLS, CLPP, BLVRB ALDH1A1 1284/4885GLA 317/4885POLB 121/4885
US-20120220772-A1 NOVEL 3-HYDROXY-5-ARYLISOXAZOLE DERIVATIVE GPR119, GPR27, NR0B1 ALDH1A1 2867/4885GLA 3554/4885POLB 4532/4885
US-20120277150-A1 NOVEL 3-HYDROXYISOTHIAZOLE 1-OXIDE DERIVATIVE GPR119, GPR27, GPR65 ALDH1A1 2508/4885GLA 3320/4885POLB 4734/4885
US-20130203739-A1 CYCLIC AMIDE DERIVATIVE GPR119, NR0B1, NR2C2 ALDH1A1 3127/4885GLA 3597/4885POLB 4340/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.